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Within the mining industry, a safe mine ventilation system is an essential component of all underground mines. The mine ventilation system is responsible for supplying fresh air to the underground, meeting the breathing requirements of worker, diluting the gas attached to the coal, discharging toxic and harmful gases, reducing the air temperature of working environment. It is very necessary to optimize a complete and reasonable scheme of mine ventilation system to ensure a safe and acceptable working environment. In this paper, the Analytic Hierarchy Process-Weight Rank Sum Ratio (AHP-WRSR) evaluation model is constructed to optimize the reconstruction scheme of mine ventilation system and a mining engineering example is used to verify the effect of this method. Specifically, based on the ventilation system transformation in Sihe coal mine as an example, a total of 20 modification schemes of 6 categories were established and the results obtained by AHP-WRSR are consistent with the field application.