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In new energy high permeability power grid, the uncertainty of new energy brings great challenges to the security and stability of the power grid. This paper proposes an adaptive grid-friendly response strategy for commercial buildings based on power cyber-physical system (CPS). Firstly, the overall framework of CPS of commercial buildings with the functions of each layer is established. Then, the procedure and model of the asynchronous cooperative adaptive grid friendly response strategy is constructed. Finally, the simulation results show that the proposed method is effective and reasonable in IEEE-14 case with commercial buildings' friendly response to the power grid. This paper provides a reference for the application of power grid friendly technology, realizes the optimal allocation of resources, and increases the safety and stability of power grid.